The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 08, 2020

Filed:

Jun. 26, 2017
Applicant:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventors:

Peter Kwong, Washington, DC (US);

Barney Graham, Rockville, MD (US);

Jason McLellan, Austin, TX (US);

Man Chen, Bethesda, MD (US);

Baoshan Zhang, Bethesda, MD (US);

Tongqing Zhou, Boyds, MD (US);

Michael Gordon Joyce, Washington, DC (US);

Yongping Yang, Potomac, DC (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/005 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); C07K 2319/03 (2013.01); C07K 2319/21 (2013.01); C07K 2319/40 (2013.01); C07K 2319/50 (2013.01); C07K 2319/70 (2013.01); C12N 2760/18522 (2013.01); C12N 2760/18534 (2013.01);
Abstract

Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the immunogens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the immunogen to the subject.


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