The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 08, 2020

Filed:

Jun. 30, 2015
Applicant:

Gwangju Institute of Science and Technology, Gwangju, KR;

Inventors:

Yong Chul Kim, Gwangju, KR;

Darren R. Williams, Gwangju, KR;

Da Woon Jung, Gwangju, KR;

Jung Eun Lee, Seoul, KR;

Shin Ae Seo, Damyang-gun, KR;

Ji Yeon Park, Yeosu-si, KR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 231/56 (2006.01); A61K 31/416 (2006.01); A61K 31/415 (2006.01); C07D 401/12 (2006.01); C12N 5/077 (2010.01);
U.S. Cl.
CPC ...
C07D 231/56 (2013.01); A61K 31/415 (2013.01); A61K 31/416 (2013.01); C07D 401/12 (2013.01); C12N 5/0654 (2013.01); C12N 2506/1323 (2013.01);
Abstract

The present invention relates to a composition for inducing cell reprogramming. The indazole derivative compound contained in the composition of the present invention shows an improved biological profile and at the same time can perform efficient cell reprogramming. In addition, unlike conventional compounds (e.g. riversine or BIO) for inducing low-molecular cell reprogramming, the indazole derivative compound of the present invention does not show cytotoxicity and thus is expected to have high growth in the market of cell therapy products when clinically applied. Conventional indazole derivative compounds have never known as a use for cell reprogramming. Compared with conventional indazole derivative compounds, the compound of the present invention has a great cell reprogramming ability while having no or little cytotoxicity.


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