IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10858319 B1

PDFFull Text
Date of Patent:
Dec. 08, 2020

Filed:

Nov. 14, 2018

Indole derivatives for use in medicine

Applicant:

Iomet Pharma Ltd., Midlothian, GB;

Inventors:

Phillip M. Cowley, West Lothian, GB;

Alan Wise, Peeblesshire, GB;

Michael Kiczun, Dundee, GB;

Susan Davis, Dundee, GB;

Assignee:

IOMet Pharma Ltd., Midlothian, GB;

Attorneys:

Yong Zhao

Anna L. Cocuzzo

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 209/42 (2006.01); A61K 45/06 (2006.01); C07D 263/58 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 471/04 (2006.01); C07D 409/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); A61K 31/4155 (2006.01); A61K 31/416 (2006.01); A61K 31/4178 (2006.01); A61K 31/4196 (2006.01); A61K 31/422 (2006.01); A61K 31/4245 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/475 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/517 (2006.01); A61K 31/5377 (2006.01); A61K 31/437 (2006.01); A61K 31/4355 (2006.01); A61K 31/424 (2006.01); A61K 31/423 (2006.01); A61K 31/4188 (2006.01); A61K 31/4184 (2006.01); A61K 31/407 (2006.01); A61K 31/405 (2006.01); A61K 31/4045 (2006.01); A61K 31/404 (2006.01);
U.S. Cl.
CPC ...
C07D 209/42 (2013.01); A61K 31/404 (2013.01); A61K 31/405 (2013.01); A61K 31/407 (2013.01); A61K 31/4045 (2013.01); A61K 31/416 (2013.01); A61K 31/4155 (2013.01); A61K 31/4178 (2013.01); A61K 31/4184 (2013.01); A61K 31/4188 (2013.01); A61K 31/4196 (2013.01); A61K 31/422 (2013.01); A61K 31/423 (2013.01); A61K 31/424 (2013.01); A61K 31/427 (2013.01); A61K 31/4245 (2013.01); A61K 31/437 (2013.01); A61K 31/4355 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/475 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 263/58 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01);
Abstract

Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the following formula: wherein X, X, X, X, and Xmay be the same or different and each is independently selected from C, N and O; each atom having a dotted line may independently have a double bond or a single bond, provided that valencies at each atom are maintained; each R, R, R, R, and Rmay be present or absent and may be the same or different and is selected from H and a substituted or unsubstituted organic group, provided that the number of such R groups present is such that the valencies of X, X, X, X, and Xare maintained; one or two Rgroups may be present and are selected from H and a substituted or unsubstituted organic group, provided that the number of Rgroups present is such that the valency of the carbon atom to which they are attached is maintained, and provided that at least one Ris an organic group comprising an atom double-bonded to an oxygen atom (preferably a carbonyl group or a sulphonyl group) at an α-, β-, or γ-position to the carbon atom to which the Ris attached and in which the atom double-bonded to an oxygen atom is also bonded to a hetero-atom.

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