The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2020
Filed:
Nov. 29, 2017
Applicant:
Neonc Technologies, Inc., Los Angeles, CA (US);
Inventor:
Thomas Chen, La Canada, CA (US);
Assignee:
NeOnc Technologies, Inc., Los Angeles, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/00 (2006.01); A61K 31/22 (2006.01); A61K 31/19 (2006.01); A61P 35/04 (2006.01); A61P 35/00 (2006.01); C07C 69/716 (2006.01); C07C 67/08 (2006.01);
U.S. Cl.
CPC ...
C07C 69/716 (2013.01); A61K 35/00 (2013.01); C07C 67/08 (2013.01);
Abstract
NEO218 (3-bromo-2-oxo-propionic acid 4-isopropenyl-cyclohex-1-enylmethyl ester), (see formula), is a novel molecule that was generated by covalent fusion of two unrelated agents: 3-bromopyruvate (3-BF; an alkylating agent that Inhibits cancer cell metabolism) and perillyi alcohol (POH; a natural monoterpene with anticancer properties). Methods of synthesizing NBO218, pharmaceutical compositions comprising NBO218 and methods of treating cancer using NBO218 are also disclosed.