The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 08, 2020

Filed:

Aug. 29, 2019
Applicant:

The General Hospital Corporation, Boston, MA (US);

Inventors:

David R. Elmaleh, Newton, MA (US);

Timothy M. Shoup, Franklin, MA (US);

Hongning Fu, Newton, MA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/04 (2006.01); C07D 471/10 (2006.01); C07H 13/10 (2006.01); C07H 15/26 (2006.01); C07C 43/253 (2006.01); C07H 13/02 (2006.01); C07C 43/192 (2006.01); C07C 43/196 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0497 (2013.01); C07C 43/192 (2013.01); C07C 43/196 (2013.01); C07C 43/253 (2013.01); C07D 471/10 (2013.01); C07H 13/02 (2013.01); C07H 13/10 (2013.01); C07H 15/26 (2013.01);
Abstract

One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.


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