The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2020
Filed:
Jan. 18, 2019
Applicant:
Case Western Reserve University, Cleveland, OH (US);
Inventors:
Eric J. Arts, Ontario, CA;
Jamie Mann, Ontario, CA;
Assignee:
CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); A61P 31/18 (2006.01); A61K 39/39 (2006.01); A61K 39/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 39/12 (2013.01); A61K 39/39 (2013.01); A61P 31/18 (2018.01); A61K 45/06 (2013.01); A61K 2039/572 (2013.01); A61K 2039/6075 (2013.01); C12N 2740/16034 (2013.01); C12N 2740/16134 (2013.01);
Abstract
A method of reducing a latent HIV-specific memory-CD4+ T cell pool in a subject includes administering to the subject at least one HIV-1 protein and a pharmaceutically acceptable carrier, wherein the at least one HIV-1 protein is derived from an allogenic infecting HIV-1 virus, and wherein the HIV-1 protein stimulates latent HIV-specific memory CD4+ T cells to induce latent HIV-1 replication resulting in HIV-specific memory-CD4+ T cell death in the subject.