The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2020
Filed:
Jun. 01, 2017
Applicant:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Inventors:
Joshua J. Coon, Middleton, WI (US);
Michael S. Westphall, Fitchburg, WI (US);
Assignee:
Wisconsin Alumni Research Foundation, Madison, WI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); G01N 33/483 (2006.01); H01J 49/00 (2006.01); H01J 49/04 (2006.01); H01J 49/26 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6848 (2013.01); G01N 33/483 (2013.01); H01J 49/0072 (2013.01); H01J 49/04 (2013.01); H01J 49/26 (2013.01); G01N 2458/00 (2013.01); G01N 2560/00 (2013.01); Y10T 436/24 (2015.01);
Abstract
Described herein are mass spectrometry systems and methods which improve the accuracy of isobaric tag-based quantification by alleviating the pervasive problem of precursor interference and co-isolation of impurities through gas-phase purification. During the gas-phase purification, the mass-to-charge ratios of precursor ions within at least a selected range are selectively changed allowing ions having similar unmodified mass-to-charge ratios to be separated before further isolation, fragmentation or analysis.