The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2020
Filed:
Jan. 04, 2018
Applicants:
Mgi Tech Co., Ltd., Shenzhen, CN;
Bgi Shenzhen, Shenzhen, CN;
Inventors:
Radoje Drmanac, Los Altos Hills, CA (US);
Snezana Drmanac, Los Altos Hills, CA (US);
Handong Li, San Jose, CA (US);
Xun Xu, Shenzhen, CN;
Matthew J. Callow, Redwood City, CA (US);
Leon Eckhardt, Soquel, CA (US);
Naibo Yang, San Jose, CA (US);
Assignees:
MGI Tech Co., Ltd., Shenzhen, CN;
BGI Shenzhen, Shenzhen, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 19/34 (2006.01); C12Q 1/6874 (2018.01); C12Q 1/6876 (2018.01); C07K 16/44 (2006.01); C12Q 1/6804 (2018.01); A61K 47/00 (2006.01); C12Q 1/6869 (2018.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6874 (2013.01); A61K 47/00 (2013.01); C07K 16/2851 (2013.01); C07K 16/44 (2013.01); C12Q 1/6804 (2013.01); C12Q 1/6869 (2013.01); C12Q 1/6876 (2013.01); C07K 2317/73 (2013.01);
Abstract
The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.