The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2020
Filed:
Jan. 09, 2014
Applicant:
Friedrich-alexander-universitaet Erlangen-nuernberg, Erlangen, DE;
Inventors:
Assignee:
Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/37 (2006.01); G01N 33/574 (2006.01); C07K 7/06 (2006.01); G01N 33/542 (2006.01); G01N 33/569 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/37 (2013.01); C07K 7/06 (2013.01); G01N 33/542 (2013.01); G01N 33/56988 (2013.01); G01N 33/574 (2013.01); G01N 33/5743 (2013.01); G01N 33/6893 (2013.01); G01N 2333/96494 (2013.01);
Abstract
The present invention relates to a method for in vitro detection and/or monitoring of a disease in a sample, based on measurement of enzymatic activity of proteases activated and secreted upon disease development, to modified peptides used for the enzymatic detection of the proteases, the use of the peptides, a kit comprising such peptides and the use of ADAM-protease activity as a surrogate marker for disease burden and activity in infectious, inflammatory, and malignant diseases, such as HIV infection and melanoma.