The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 01, 2020

Filed:

Apr. 05, 2019
Applicants:

The Regents of the University of Michigan, Ann Arbor, MI (US);

Board of Trustees of Michigan State University, East Lansing, MI (US);

Inventors:

Scott D. Larsen, South Lyon, MI (US);

Richard Neubig, East Lansing, MI (US);

Kim Hutchings, Dexter, MI (US);

Dylan Kahl, Ann Arbor, MI (US);

Erika Mathes Lisabeth, Howell, MI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 271/113 (2006.01); C07D 271/06 (2006.01); C07D 413/12 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 271/113 (2013.01); A61P 35/00 (2018.01); C07D 271/06 (2013.01); C07D 413/12 (2013.01);
Abstract

Disclosed herein are inhibitors of Rho/MRTF/SRF-mediated gene transcription, and methods for their use in treating or preventing diseases such as cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.


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