The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2020
Filed:
Feb. 09, 2017
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Arizona Board of Regents on Behalf of the University of Arizona, Tucson, AZ (US);
Thomas Joseph Sayers, Boonsboro, MD (US);
Alan David Brooks, Frederick, MD (US);
Curtis J. Henrich, Rockville, MD (US);
Poonam Tewary, Frederick, MD (US);
James Brislin McMahon, Frederick, MD (US);
Leslie Gunatilaka, Tucson, AZ (US);
Ya-Ming Xu, Tucson, AZ (US);
Kithsiri Wijeratne, Tucson, AZ (US);
Abstract
Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, which method comprises contacting the cancer cells with an apoptosis inducing ligand in conjunction with an effective amount of a compound of the formula: (I), wherein R-Rare as described herein. Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with the compound described herein and also contacting the cancer cells with an apoptosis inducing ligand, whereby apoptosis is induced in the cancer cells.