The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 01, 2020

Filed:

May. 30, 2018
Applicant:

Abbott Laboratories, Abbott Park, IL (US);

Inventors:

Beth McQuiston, Abbott Park, IL (US);

Frederick Korley, Abbott Park, IL (US);

Agim Beshiri, Abbott Park, IL (US);

Jaime Marino, Abbott Park, IL (US);

Saul Datwyler, Abbott Park, IL (US);

Assignee:

Abbott Laboratories, Abbott Park, IL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C12Q 1/68 (2018.01); G01N 33/567 (2006.01); A61B 5/00 (2006.01); G01N 33/68 (2006.01); G01N 33/543 (2006.01); G01N 33/577 (2006.01); C12Q 1/6883 (2018.01); G01N 33/533 (2006.01); G01N 33/564 (2006.01);
U.S. Cl.
CPC ...
A61B 5/4064 (2013.01); G01N 33/54346 (2013.01); G01N 33/54366 (2013.01); G01N 33/577 (2013.01); G01N 33/6896 (2013.01); C12Q 1/6883 (2013.01); G01N 33/533 (2013.01); G01N 33/564 (2013.01); G01N 33/6893 (2013.01); G01N 2800/28 (2013.01); G01N 2800/52 (2013.01); G01N 2800/56 (2013.01); G01N 2800/60 (2013.01);
Abstract

Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or a moderate, severe, or moderate to severe traumatic brain injury (TBI), by detecting levels of cardiac troponin I (cTnI) and one or more early biomarkers which are not cTnI, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), glial fibrillary acidic protein (GFAP), or a combination thereof, in biological samples taken from a human subject at time points within about 24 hours of injury after the subject has sustained or may have sustained the injury to the head.


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