The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2020
Filed:
Apr. 01, 2015
Cornell University, Ithaca, NY (US);
Sloan-kettering Institute for Cancer Research, New York, NY (US);
David C. Lyden, New York, NY (US);
Hector Peinado Selgas, New York, NY (US);
Haiying Zhang, New York, NY (US);
Basant Kumar Thakur, New York, NY (US);
Annette Becker, New York, NY (US);
Jacqueline Bromberg, West Nyack, NY (US);
CORNELL UNIVERSITY, Ithaca, NY (US);
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, New York, NY (US);
Abstract
The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recovering the exosomes from the sample, and isolating the double-stranded DNA from within the exosomes. The isolated double-stranded DNA is then used to detect the presence or absence of one or more genetic mutations associated with cancer, quantify the amount of isolated double-stranded DNA from the recovered exosomes in the sample, detect the methylation status of the isolated double-stranded DNA, or quantify the amount isolated double-stranded DNA able to enter a recipient cell. The prognosing, treating, or managing treatment is carried out based on this information.