The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2020
Filed:
Jul. 22, 2015
Applicant:
Orum Therapeutics Inc., Daejeon, KR;
Inventors:
Yong-Sung Kim, Gyeonggi-do, KR;
Dong-Ki Choi, Gyeonggi-do, KR;
Seung-Min Shin, Seoul, KR;
Sung-Hoon Kim, Seoul, KR;
Assignee:
ORUM THERAPEUTICS INC., Daejeon, KR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/32 (2006.01); C07K 16/40 (2006.01); C07K 16/28 (2006.01); C07K 16/00 (2006.01); C07K 16/46 (2006.01); C07K 16/30 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C07K 16/32 (2013.01); C07K 16/00 (2013.01); C07K 16/2863 (2013.01); C07K 16/30 (2013.01); C07K 16/40 (2013.01); C07K 16/46 (2013.01); G01N 33/574 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/515 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/73 (2013.01); C07K 2317/77 (2013.01); C07K 2317/82 (2013.01); C07K 2317/92 (2013.01);
Abstract
A method is described of localizing an intact immunoglobulin-format antibody in cytosol by permeating the cell membrane, thereby avoiding the necessity to use a special external protein delivery system. The method achieves high effects on the treatment and diagnosis of tumor and disease-related factors that show structurally complex interactions through a wide and flat surface between protein and protein.