The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 24, 2020

Filed:

Aug. 21, 2018
Applicants:

Technische Universität München, Munich, DE;

Xl-protein Gmbh, Freising, DE;

Inventors:

Arne Skerra, Freising, DE;

Uli Binder, Freising, DE;

Martin Schlapschy, Freising, DE;

Assignees:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); C07K 14/56 (2006.01); C07K 7/08 (2006.01); A61K 47/64 (2017.01); C07K 16/00 (2006.01); C07K 14/615 (2006.01); A61K 39/00 (2006.01); A61K 38/00 (2006.01); A61K 31/7088 (2006.01); C12N 15/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/00 (2013.01); A61K 47/645 (2017.08); C07K 7/08 (2013.01); C07K 14/001 (2013.01); C07K 14/56 (2013.01); C07K 14/615 (2013.01); C07K 16/00 (2013.01); A61K 31/7088 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/55 (2013.01); C07K 2319/31 (2013.01); C12N 15/00 (2013.01);
Abstract

The present invention relates to a biosynthetic random coil polypeptide or a biosynthetic random coil polypeptide segment or biosynthetic conjugate, in which the biosynthetic random coil polypeptide, the biosynthetic random coil polypeptide segment, or the biosynthetic conjugate comprises an amino acid sequence consisting solely of proline and alanine amino acid residues, wherein the amino acid sequence consists of at least about 50 proline (Pro) and alanine (Ala) amino acid residues. The at least about 50 proline (Pro) and alanine (Ala) amino acid residues may be (a) fconstituent(s) of a heterologous polypeptide or an heterologous polypeptide construct. Also uses and methods of use of these biosynthetic random coil polypeptides or polypeptide segments or conjugates are described.


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