The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2020
Filed:
Feb. 21, 2020
Applicant:
Buck Institute for Research on Aging, Novato, CA (US);
Inventors:
Varghese John, San Francisco, CA (US);
Dale E. Bredesen, Novato, CA (US);
Assignee:
BUCK INSTITUTE FOR RESEARCH ON AGING, Novato, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 471/04 (2006.01); A61P 25/28 (2006.01); A61K 31/437 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/437 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); A61P 25/28 (2018.01); C07D 471/04 (2013.01);
Abstract
In certain embodiments compounds corresponding in structure to the formula: are provided that are effective to lower p-tau and/or to prevent or reduce elevation of p-tau, particularly in response to stress (e.g., elevated cortisol levels). The compounds are useful in the treatment or prophylaxis of pathologies characterized by abnormal amyloid plaque and or tangle formation and/or deposition.