The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2020
Filed:
Jan. 21, 2020
Biohaven Pharmaceutical Holding Company Ltd., New Haven, CT (US);
Rutgers, the State University of New Jersey, New Brunswick, NJ (US);
Garry Robert Smith, Royersford, PA (US);
Allen B. Reitz, Lansdale, PA (US);
Mark McDonnell, Lansdale, PA (US);
Suzie Chen, Highland Park, NJ (US);
Matthew D. Vera, Collegeville, PA (US);
Benjamin E. Blass, Eagleville, PA (US);
Jeffrey Claude Pelletier, Lafayette Hill, PA (US);
Venkata N. Velvadapu, Philadelphia, PA (US);
Jay Edward Wrobel, Lawrenceville, NJ (US);
Biohaven Pharmaceutical Holding Company Ltd., New Haven, CT (US);
Rutgers, The State University of New Jersey, New Brunswick, NJ (US);
Abstract
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.