The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2020
Filed:
Oct. 04, 2018
Applicant:
Washington University, St. Louis, MO (US);
Inventors:
Gerald W. Dorn, II, St. Louis, MO (US);
James Janetka, St. Louis, MO (US);
Assignee:
WASHINGTON UNIVERSITY, St. Louis, MO (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/4196 (2006.01); C07D 249/12 (2006.01); C07D 405/12 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
C07D 249/12 (2013.01); A61P 25/28 (2018.01); C07D 405/12 (2013.01);
Abstract
Compositions comprising small molecule mitofusin agonists are described. The mitofusin modulating agents are useful for treating diseases or disorders associated with a mitochondria-associated disease, disorder, or condition such as diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2), or mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations, and screening methods for identifying compounds that regulate mitochondrial function are also described.