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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10844017 B1

PDFFull Text
Expired
Date of Patent:
Nov. 24, 2020

Filed:

Feb. 09, 2018

Biaryl compound, preparation method and use thereof

Applicant:

Fudan University, Shanghai, CN;

Inventors:

Yonghui Wang, Shanghai, CN;

Yafei Huang, Shanghai, CN;

Ruomeng Qiu, Shanghai, CN;

Ting Tang, Shanghai, CN;

Assignee:

FUDAN UNIVERSITY, Shanghai, CN;

Attorney:

Alleman Hall Creasman & Tuttle LLP

Primary Examiner:

Kristin A Vajda

Int. Cl.
CPC ...
C07D 213/64 (2006.01); C07C 255/60 (2006.01); C07D 231/12 (2006.01); C07D 213/56 (2006.01); C07C 317/32 (2006.01); C07D 213/71 (2006.01); C07F 9/28 (2006.01); C07C 317/40 (2006.01); C07D 205/04 (2006.01); C07D 207/09 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 213/64 (2013.01); A61P 35/00 (2018.01); C07C 255/60 (2013.01); C07C 317/32 (2013.01); C07C 317/40 (2013.01); C07D 205/04 (2013.01); C07D 207/09 (2013.01); C07D 213/56 (2013.01); C07D 213/71 (2013.01); C07D 231/12 (2013.01); C07F 9/28 (2013.01);
Abstract

The present invention belongs to the technical field of chemical pharmaceuticals, and relates to a compound represented by general formula (I) or formula (II) and a preparation method thereof. The compounds are biaryl derivatives with RORγt activation activity. The biaryl derivatives disclosed in this invention can effectively activate the RORγt protein receptor, and thereby promote the differentiation of Th17 cells and increasing the production of IL-17, which can be used as an immune modulator for the treatment of various cancers or viral infection-related diseases.

Find Patent Forward Citations

Wang, Yonghui. (2020). Biaryl compound, preparation method and use thereof (U.S. Patent No. 10844017). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10844017

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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