The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2020
Filed:
Jan. 11, 2018
Linhai Tianyu Pharmaceutical Co., Ltd., Zhejiang, CN;
Shanghai Qixun Pharmaceutical Technology Co., Ltd., Shanghai, CN;
Kunlun Qiu, Shanghai, CN;
Wenbo Wang, Shanghai, CN;
Qianjie Yu, Shanghai, CN;
Botao Li, Shanghai, CN;
Xiongdong Lian, Shanghai, CN;
Gongyong Li, Shanghai, CN;
Linhai Tianyu Pharmaceutical Co., Ltd., Zhejiang, CN;
Shanghai Qixun Pharmaceutical Technology Co., Ltd., Shanghai, CN;
Abstract
Disclosed is a method for preparing a 2-fluoroacrylate, comprising the steps of: (1) mixing a vinyl ether having the structure of formula A with dichloromonofluoromethane to yield a substituted cyclopropane compound having the structure of formula B; (2) mixing the substituted cyclopropane compound having the structure of formula B with ROH to yield an acetal product having the structure of formula C, followed by hydrolysis to yield 2-fluoroacrylaldehyde having the structure of formula D; or reacting the substituted cyclopropane compound having the structure of formula B with water to yield 2-fluoroacrylaldehyde having the structure of formula D via hydrolysis; (3) oxidizing 2-fluoroacrylaldehyde having the structure of formula D to yield 2-fluoroacrylic acid having the structure of formula E; and (4) mixing 2-fluoroacrylic acid having the structure of formula E with ROH to yield a 2-fluoroacrylate having the structure of formula F.