The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2020
Filed:
Mar. 16, 2018
Applicant:
Emory University, Atlanta, GA (US);
Inventors:
Eric Ortlund, Decatur, GA (US);
Suzanne Mays, Marietta, GA (US);
Nathan Jui, Decatur, GA (US);
Autumn Flynn, Decatur, GA (US);
Michael Dugan, Atlanta, GA (US);
Assignee:
Emory University, Atlanta, GA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 59/54 (2006.01); C07C 35/50 (2006.01); C07C 39/23 (2006.01); C07C 43/23 (2006.01); C07C 49/683 (2006.01); C07C 49/83 (2006.01); C07C 215/70 (2006.01); C07C 255/47 (2006.01); C07C 271/34 (2006.01); C07C 307/02 (2006.01); C07C 309/66 (2006.01); C07D 249/04 (2006.01); C07F 9/09 (2006.01); C07F 9/572 (2006.01);
U.S. Cl.
CPC ...
C07C 59/54 (2013.01); C07C 35/50 (2013.01); C07C 39/23 (2013.01); C07C 43/23 (2013.01); C07C 49/683 (2013.01); C07C 49/83 (2013.01); C07C 215/70 (2013.01); C07C 255/47 (2013.01); C07C 271/34 (2013.01); C07C 307/02 (2013.01); C07C 309/66 (2013.01); C07D 249/04 (2013.01); C07F 9/091 (2013.01); C07F 9/572 (2013.01); C07C 2602/22 (2017.05);
Abstract
This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of hexahydropentalene. In certain embodiments, this disclosure relates to methods of treating or preventing cancer, diabetes, or cardiovascular disease by administering an effective amount of a hexahydropentalene derivative disclosed herein.