The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 24, 2020

Filed:

Sep. 10, 2018
Applicant:

On Target Laboratories, Llc, West Lafayette, IN (US);

Inventors:

Sumith A Kularatne, West Lafayette, IN (US);

Mini Thomas, West Lafayette, IN (US);

Assignee:

On Target Laboratories, LLC, West Lafayette, IN (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); A61B 8/00 (2006.01); A61B 10/00 (2006.01); A61K 49/00 (2006.01); G01N 21/64 (2006.01); C07K 5/087 (2006.01); C07K 5/11 (2006.01); C07K 7/06 (2006.01); C07K 5/062 (2006.01); C07D 209/20 (2006.01); C07K 5/083 (2006.01); G01N 33/574 (2006.01); C07K 7/02 (2006.01); C07K 5/072 (2006.01); C07K 5/078 (2006.01); C07K 5/065 (2006.01); C07K 5/09 (2006.01); G01N 33/58 (2006.01); A61K 49/16 (2006.01);
U.S. Cl.
CPC ...
A61K 49/0052 (2013.01); A61K 49/0032 (2013.01); A61K 49/0034 (2013.01); A61K 49/0056 (2013.01); C07D 209/20 (2013.01); C07K 5/0606 (2013.01); C07K 5/06026 (2013.01); C07K 5/06078 (2013.01); C07K 5/06095 (2013.01); C07K 5/06121 (2013.01); C07K 5/06147 (2013.01); C07K 5/06156 (2013.01); C07K 5/0806 (2013.01); C07K 5/0812 (2013.01); C07K 5/0817 (2013.01); C07K 5/1019 (2013.01); C07K 7/02 (2013.01); C07K 7/06 (2013.01); G01N 21/6428 (2013.01); G01N 33/57434 (2013.01); G01N 33/57492 (2013.01); G01N 33/582 (2013.01); A61K 49/0017 (2013.01); A61K 49/16 (2013.01); C12Y 304/17021 (2013.01); G01N 2021/6439 (2013.01); G01N 2333/948 (2013.01);
Abstract

The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.


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