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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10842853 B1

PDFFull Text
Date of Patent:
Nov. 24, 2020

Filed:

May. 22, 2018

Viral vectors encoding recombinant fix with increased expression for gene therapy of hemophilia b

Applicants:

Baxalta Incorporated, Bannockburn, IL (US);

Baxalta Gmbh, Glattpark, CH;

Inventors:

Franziska Horling, Gaenserndorf, AT;

Johannes Lengler, Vienna, AT;

Falko-Gunter Falkner, Orth/Donau, AT;

Hanspeter Rottensteiner, Vienna, AT;

Friedrich Scheiflinger, Vienna, AT;

Assignees:

Baxalta Incorporated, Bannockburn, IL (US);

Baxalta GmbH;

Attorney:

Morgan, Lewis & Bockius LLP

Primary Examiner:

Shin Lin Chen

Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/86 (2006.01); A61K 38/48 (2006.01); A61K 48/00 (2006.01); C07K 14/745 (2006.01); A61P 7/04 (2006.01); A61K 31/7088 (2006.01); A61K 35/76 (2015.01); C07K 14/005 (2006.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 38/4846 (2013.01); A61K 31/7088 (2013.01); A61K 35/76 (2013.01); A61K 48/0058 (2013.01); A61K 48/0066 (2013.01); A61P 7/04 (2018.01); C07K 14/005 (2013.01); C07K 14/745 (2013.01); C12N 15/62 (2013.01); C12N 15/85 (2013.01); C12N 15/86 (2013.01); C12N 2750/14143 (2013.01); C12N 2800/22 (2013.01); C12N 2830/008 (2013.01); C12N 2830/42 (2013.01);
Abstract

Codon-altered polynucleotides encoding Factor IX variants for expression in mammalian cells are provided, including sequences with high nucleotide sequence identity to the CS02, CS03, CS04, CS05, and CS06 sequences. Mammalian gene therapy vectors, such as adeno-associated viral vectors, and methods for treating hemophilia B using those vectors are also provided.

Find Patent Forward Citations

Horling, Franziska. (2020). Viral vectors encoding recombinant fix with increased expression for gene therapy of hemophilia b (U.S. Patent No. 10842853). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10842853

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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