The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 24, 2020

Filed:

Jun. 15, 2018
Applicant:

Creative Medical Technologies, Inc., Phoenix, AZ (US);

Inventors:

Thomas Ichim, San Diego, CA (US);

Amit Patel, Salt Lake City, UT (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61K 35/28 (2015.01); A61K 9/00 (2006.01); C12N 5/0783 (2010.01); C07K 14/71 (2006.01); C07K 14/435 (2006.01); A61K 38/45 (2006.01); A61K 38/22 (2006.01); A61K 38/19 (2006.01); A61P 25/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 9/0019 (2013.01); A61K 35/28 (2013.01); A61K 38/193 (2013.01); A61K 38/22 (2013.01); A61K 38/45 (2013.01); A61P 25/00 (2018.01); C07K 14/435 (2013.01); C07K 14/71 (2013.01); C12N 5/0637 (2013.01); C12Y 207/10 (2013.01); C12N 2500/02 (2013.01); C12N 2501/165 (2013.01); C12N 2501/998 (2013.01);
Abstract

Disclosed are method of enhancing perispinal perfusion in a patient suffering from reduced perfusion of the lower back through administration of T regulatory cells alone capable of stimulating angiogenesis directly or through enhancement of angiogenic activities of cellular therapies. Said cellular therapies possessing angiogenic activities include mesenchymal stem cells, hematopoietic stem cells and endothelial progenitor cells. In one embodiment of the invention, administration of T regulatory cells is performed that are expanded ex vivo. For certain embodiment of the invention T regulatory cells may be autologous or allogeneic.


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