The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2020
Filed:
Mar. 09, 2016
Applicant:
Keio University, Tokyo, JP;
Inventor:
Minoru Ko, Tokyo, JP;
Assignee:
KEIO UNIVERSITY, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/0793 (2010.01); C12N 5/071 (2010.01); C12N 5/0735 (2010.01); C12N 5/0797 (2010.01); C12N 5/16 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0619 (2013.01); C12N 5/0606 (2013.01); C12N 5/067 (2013.01); C12N 5/0623 (2013.01); C12N 5/16 (2013.01); C12N 2501/60 (2013.01); C12N 2501/65 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2510/00 (2013.01);
Abstract
Provided is a method of differentiating a pluripotent stem cell of mammalian origin into a desired cell type by predicting the direction of cell differentiation to be caused by induction of expression of a transcription factor. A human gene expression correlation matrix using human cells has been newly created, and further, it has been confirmed that human pluripotent stem cells can be differentiated into a desired cell type by introducing, into the human pluripotent stem cells, a transcription factor cocktail selected from the matrix.