The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2020
Filed:
Oct. 11, 2017
Zhejiang Huahai Pharmaceutical Co., Ltd., Zhejiang, CN;
Shanghai Syncores Technologies, Inc., Shanghai, CN;
Zeng Li, Shanghai, CN;
Xiaosong Cheng, Shanghai, CN;
Xianliang He, Shanghai, CN;
Jicheng Zhang, Shanghai, CN;
Luning Huang, Shanghai, CN;
Anping Tao, Shanghai, CN;
Hong Gu, Shanghai, CN;
Zhejiang Huahai Pharmaceutical Co., Ltd., Zhejiang, CN;
Shanghai Syncores Technologies, Inc., Shanghai, CN;
Abstract
The present application provides a method for preparing nintedanib. The method of the present application is carried out by using 4-halo-3-nitro-benzoic acid methyl ester (compound II) and 3-oxo-3-phenylpropionate (compound III) as raw materials, and preparing nintedanib via intermediates of methyl 4-(1-alkoxy-1,3-dioxo-3-phenyl propan-2-yl)-3-nitrobenzoate (compound IV) and methyl 3-benzoyl-2-oxoindoline-6-formate (compound V). The method for preparing nintedanib (I) provided by the present application has the advantages of using easily obtained raw materials, having a simple process, being cost effective and environmentally friendly, and is suitable for industrial-scale production.