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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10836743 B1

PDFFull Text
Date of Patent:
Nov. 17, 2020

Filed:

Mar. 16, 2017

Fluorinated cyclopropylamine compound, preparation method therefor, pharmaceutical composition thereof, and uses thereof

Applicant:

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;

Inventors:

Hong Liu, Shanghai, CN;

Jia Li, Shanghai, CN;

Jiang Wang, Shanghai, CN;

Mingbo Su, Shanghai, CN;

Shuni Wang, Shanghai, CN;

Yubo Zhou, Shanghai, CN;

Wei Zhu, Shanghai, CN;

Wei Xu, Shanghai, CN;

Chunpu Li, Shanghai, CN;

Hualiang Jiang, Shanghai, CN;

Kaixian Chen, Shanghai, CN;

Assignee:

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai, CN;

Attorney:

Panitch Schwarze Belisario & Nadel LLP

Primary Examiner:

Kristin A Vajda

Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 401/06 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 205/04 (2006.01); C07D 265/30 (2006.01); C07D 211/38 (2006.01); C07D 211/96 (2006.01); A61P 35/00 (2006.01); C07D 409/06 (2006.01); C07C 233/41 (2006.01); C07D 211/46 (2006.01); C07C 311/20 (2006.01); C07C 233/43 (2006.01); C07C 271/24 (2006.01); C07C 211/37 (2006.01); C07D 417/14 (2006.01); C07D 401/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61P 35/00 (2018.01); C07C 211/37 (2013.01); C07C 233/41 (2013.01); C07C 233/43 (2013.01); C07C 271/24 (2013.01); C07C 311/20 (2013.01); C07D 205/04 (2013.01); C07D 211/38 (2013.01); C07D 211/46 (2013.01); C07D 211/96 (2013.01); C07D 265/30 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 409/06 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07B 2200/07 (2013.01); C07C 2601/02 (2017.05); C07C 2601/14 (2017.05); Y02P 20/55 (2015.11);
Abstract

Provided is a fluorinated cyclopropylamine compound represented by formula I, a racemate thereof, an R-isomer thereof, an S-isomer thereof, a pharmaceutical salt thereof, and a mixture thereof. Also provided are pharmaceutical compositions containing the compound, a preparation method for the compound, and uses thereof as a lysine specific demethylase 1 (LSD1) inhibitor, and in the treatment of cancers.

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