The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2020
Filed:
Oct. 03, 2017
Applicant:
Ada Foundation, Chicago, IL (US);
Inventor:
Jirun Sun, Rockville, MD (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 213/76 (2006.01); C07D 213/20 (2006.01); C08F 220/34 (2006.01); G01N 33/543 (2006.01); G01N 33/68 (2006.01); C08F 26/06 (2006.01); C08F 226/06 (2006.01); C08F 126/06 (2006.01);
U.S. Cl.
CPC ...
C07D 213/76 (2013.01); C07D 213/20 (2013.01); C08F 220/34 (2013.01); G01N 33/5438 (2013.01); G01N 33/6887 (2013.01); C08F 26/06 (2013.01); C08F 126/06 (2013.01); C08F 226/06 (2013.01); G01N 2333/78 (2013.01);
Abstract
A new azo-type quaternary pyridinium salt (Azo-QPS) shows enhanced activity at acidic conditions (e.g., pH=5); in neutral or basic conditions, this new Azo-QPS shows a much lower level (2-50 times less) anti-bacterial activity. The use of such a 'stimulus-enhance' antibiotic can response to the proliferation of bacteria directly. It helps reduce or prevent the build-up of potent antibacterial agents in the oral environment. The antibacterial properties of Azo-QPS are 'activated' when the environmental pH becomes acidic; this acidic pH may be indicative of the accumulation ofor the initiation of tooth decay.