The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2020
Filed:
Jun. 05, 2017
Applicant:
Temple University—of the Commonwealth System of Higher Education, Philadelphia, PA (US);
Inventors:
Walter J. Koch, Malvern, PA (US);
Sarah M. Schumacher-Bass, Landsdale, PA (US);
Assignee:
TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 9/04 (2006.01); A61K 48/00 (2006.01); A61K 38/43 (2006.01); C12N 15/63 (2006.01); C12N 15/85 (2006.01); C12N 9/12 (2006.01); C07K 14/47 (2006.01); C12N 15/11 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 38/43 (2013.01); A61K 48/00 (2013.01); A61P 9/04 (2018.01); C12N 9/12 (2013.01); C12N 15/63 (2013.01); C12N 15/85 (2013.01); C12Y 207/11015 (2013.01); A61K 38/00 (2013.01); C07K 14/47 (2013.01); C12N 15/11 (2013.01); C12N 2750/14143 (2013.01);
Abstract
This invention is generally related to novel compositions for treating or preventing heart failure. Specifically, the disclosure provides a composition comprising an amino-terminal domain of Beta.adrenergic receptor kinase-1 (Beta.ARKnt) peptide, or a nucleic acid encoding Beta.ARKnt. Further disclosed are methods of using the compositions for treating or preventing heart failure in a subject or for altering Beta.-adrenergic receptor (Beta.AR) density in a subject.