The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2020
Filed:
Feb. 27, 2018
Applicant:
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Jennifer M. Knipe, Austin, TX (US);
Laura E. Strong, Austin, TX (US);
Nicholas A. Peppas, Austin, TX (US);
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/32 (2006.01); A61K 38/10 (2006.01); A61K 38/08 (2019.01); A61K 38/06 (2006.01); A61K 38/16 (2006.01); A61K 9/16 (2006.01); A61K 9/51 (2006.01); C12N 15/11 (2006.01); A61K 9/50 (2006.01); A61K 38/28 (2006.01); C08L 33/02 (2006.01); C08L 39/06 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 47/32 (2013.01); A61K 9/1635 (2013.01); A61K 9/5026 (2013.01); A61K 9/5138 (2013.01); A61K 38/06 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61K 38/16 (2013.01); A61K 38/28 (2013.01); C08L 33/02 (2013.01); C08L 39/06 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01);
Abstract
In some aspects, methacrylate co-polymers crosslinked with an enzymatically cleavable peptide linker are provided and may be used for the oral delivery of a therapeutic. The peptide linker may be cleavable by an enzyme in the small intestine and may allow for the delivery of a therapeutic protein or nucleic acid to the small intestine. Also provided are methods of using the polymers for the treatment of a disease.