The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2020
Filed:
Oct. 10, 2016
Dongguk University Gyeongju Campus Industry-academy Cooperation Foundation, Gyeongju-si, KR;
Abstract
The present invention relates to a pharmaceutical composition for preventing or treating ovotoxicity, and more specifically, to a pharmaceutical composition for preventing or treating ovotoxicity, containing anBentham extract. According to the present invention, theBentham extract concentration-dependently increases DPPH free radical scavenging activity so as to have excellent antioxidant activity, inhibits apoptosis of ovarian cells, and activates a PI3K/Akt signaling pathway so as to have a significant protective effect against ovotoxicity to be caused by 4-vinylcyclohexene diepoxide (VCD), thereby being usable as a medicine and a health functional food, which are useful for alleviating, preventing, inhibiting or treating ovotoxicity, premature ovarian failure and the like. Therefore, subfertility treatment or prevention, premature ovarian failure, a menopausal disorder in the premenopausal period, and the like can be considered application examples related thereto.