The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2020
Filed:
Feb. 21, 2018
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Marc A. Gavin, Vashon, WA (US);
Gunasekaran Kannan, Daly City, CA (US);
Li Li, San Bruno, CA (US);
Joshua T. Pearson, San Francisco, CA (US);
Margaret Karow, Santa Rosa Valley, CA (US);
Assignee:
Amgen Inc., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/55 (2006.01); C07K 16/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/55 (2013.01); C07K 16/00 (2013.01); A61K 38/00 (2013.01); C07K 2317/41 (2013.01); C07K 2317/52 (2013.01); C07K 2317/524 (2013.01); C07K 2317/71 (2013.01); C07K 2317/94 (2013.01); C07K 2319/21 (2013.01); C07K 2319/30 (2013.01); C07K 2319/43 (2013.01);
Abstract
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.