The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2020
Filed:
Feb. 07, 2020
Applicant:
Krystal Biotech, Inc., Pittsburgh, PA (US);
Inventors:
Trevor Parry, San Diego, CA (US);
Suma Krishnan, San Francisco, CA (US);
Pooja Agarwal, Mars, PA (US);
Assignee:
KRYSTAL BIOTECH, INC., Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 48/00 (2006.01); A61P 11/00 (2006.01); C07K 14/47 (2006.01); C12N 15/63 (2006.01); C12N 15/86 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4712 (2013.01); A61K 9/0073 (2013.01); A61K 38/1709 (2013.01); A61K 48/0075 (2013.01); A61P 11/00 (2018.01); C12N 15/86 (2013.01); A61K 9/0075 (2013.01); A61K 9/0078 (2013.01); C12N 2710/16011 (2013.01); C12N 2710/16041 (2013.01); C12N 2710/16043 (2013.01); C12N 2710/16071 (2013.01); C12N 2710/16111 (2013.01); C12N 2710/16511 (2013.01); C12N 2710/16611 (2013.01); C12N 2710/16621 (2013.01); C12N 2710/16632 (2013.01); C12N 2710/16643 (2013.01); C12N 2710/16671 (2013.01); C12N 2710/16711 (2013.01);
Abstract
The present disclosure provides recombinant nucleic acids comprising one or more polynucleotides encoding a cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide (e.g., a human CFTR polypeptide); viruses comprising the recombinant nucleic acids; compositions and formulations comprising the recombinant nucleic acids and/or viruses; methods of their use (e.g., for the treatment of a chronic lung disease, such as cystic fibrosis); and articles of manufacture or kits thereof.