The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2020
Filed:
Jul. 14, 2017
Vib Vzw, Ghent, BE;
Katholieke Universiteit Leuven, K.u.leuven R&d, Leuven, BE;
VIB VZW, Ghent, BE;
Katholieke Universiteit Leuven, K.U.Leuven R&D, Leuven, BE;
Abstract
The present invention relates to the field of disorders of the central nervous system, in particular neurological and psychiatric disorders, and the prevention and/or treatment thereof. In particular, the present invention relates to the finding that soluble amyloid precursor protein a (sAPPα) presents a particular binding site, which allows for binding to the GABAR1a receptor, thereby causing an agonistic effect through specific binding to Sushi domain 1 of GABAR1a. As a result, the frequencies of excitatory and inhibitory postsynaptic currents are reduced. Accordingly, the invention provides compounds able to interfere with the association of sAPPα with Sushi domain 1 of GABAR1a and as such with selective impairment of GABAR1sa beneficial in neurological and psychiatric disorders. The invention as well provides methods and (high content) screening assays for the production of said compounds.