The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2020
Filed:
Dec. 16, 2016
Applicant:
The Board of Regents of the University of Texas System, Austin, TX (US);
Inventors:
Jinming Gao, Plano, TX (US);
Yuliang Liu, New York, NY (US);
Qi Wei, Dallas, TX (US);
Xinpeng Ma, Cambridge, MA (US);
Gang Huang, Plano, TX (US);
Assignee:
The Board of Regents of the University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 50/32 (2006.01); C07C 311/08 (2006.01); C07C 311/21 (2006.01); C07C 225/30 (2006.01); C07C 233/91 (2006.01); C07C 233/18 (2006.01); C07C 271/30 (2006.01); C07C 205/46 (2006.01); C07C 311/09 (2006.01); C07C 233/31 (2006.01); C07D 317/70 (2006.01); C07C 311/51 (2006.01); A61K 9/00 (2006.01); A61K 9/51 (2006.01); A61P 35/00 (2006.01); C07C 233/33 (2006.01); C07C 233/42 (2006.01); C07D 295/116 (2006.01);
U.S. Cl.
CPC ...
C07C 50/32 (2013.01); A61K 9/0019 (2013.01); A61K 9/5123 (2013.01); A61K 9/5146 (2013.01); A61P 35/00 (2018.01); C07C 205/46 (2013.01); C07C 225/30 (2013.01); C07C 233/18 (2013.01); C07C 233/31 (2013.01); C07C 233/33 (2013.01); C07C 233/42 (2013.01); C07C 233/91 (2013.01); C07C 271/30 (2013.01); C07C 311/08 (2013.01); C07C 311/09 (2013.01); C07C 311/21 (2013.01); C07C 311/51 (2013.01); C07D 295/116 (2013.01); C07D 317/70 (2013.01); C07C 2601/14 (2017.05); C07C 2602/10 (2017.05);
Abstract
Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R, R, R, R, R, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.