The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 10, 2020

Filed:

Apr. 09, 2019
Applicant:

Ac Immune SA, Lausanne, CH;

Inventors:

Emma Fiorini, Lausanne, CH;

Marija Vukicevic Verhille, Lausanne, CH;

Maria Pihlgren Bosch, Lausanne, CH;

Assignee:

AC Immune SA, Lausanne, CH;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 39/00 (2006.01); A61K 9/127 (2006.01); A61K 39/05 (2006.01); A61K 39/08 (2006.01); A61K 39/245 (2006.01); A61P 25/28 (2006.01); A61K 39/39 (2006.01); C07K 14/005 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0005 (2013.01); A61K 9/127 (2013.01); A61K 39/0003 (2013.01); A61K 39/0007 (2013.01); A61K 39/05 (2013.01); A61K 39/08 (2013.01); A61K 39/245 (2013.01); A61K 39/39 (2013.01); A61P 25/28 (2018.01); C07K 14/005 (2013.01); A61K 2039/55516 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55572 (2013.01); A61K 2039/57 (2013.01); A61K 2039/575 (2013.01); A61K 2039/58 (2013.01); A61K 2039/627 (2013.01); A61K 2039/645 (2013.01); A61K 2039/70 (2013.01); C07K 2319/33 (2013.01); C07K 2319/55 (2013.01); C12N 2710/16232 (2013.01); C12N 2710/16234 (2013.01); C12N 2760/16033 (2013.01);
Abstract

A liposomal vaccine composition comprises a β-amyloid (Aβ)-derived peptide antigen displayed on the surface of the liposome. The vaccine composition also comprises a peptide comprising a universal T-cell epitope encapsulated within the liposome. The vaccine composition also comprises an adjuvant, which may form part of the liposome and may be displayed at least in part on the surface of the liposome. These vaccine compositions are used for treating, preventing, inducing a protective immune response against or alleviating the symptoms associated with an amyloid-beta associated disease or condition or a condition characterised by, or associated with, loss of cognitive memory capacity in a subject. The vaccine compositions may be provided as a kit. Related methods of producing a liposomal vaccine composition are also provided.


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