The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 10, 2020

Filed:

Feb. 23, 2017
Applicant:

Emory University, Atlanta, GA (US);

Inventors:

Young-Sup Yoon, Atlanta, GA (US);

Ji Woong Han, Decatur, GA (US);

Assignee:

Emory University, Atlanta, GA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/28 (2015.01); C07D 239/95 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C12N 5/0775 (2010.01); A61K 35/44 (2015.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); A61K 35/44 (2013.01); C07D 239/95 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C12N 5/0663 (2013.01); C12N 2501/065 (2013.01); C12N 2501/40 (2013.01);
Abstract

This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered cells comprising mixing isolated cells with compositions disclosed herein under conditions such that epigenetically altered cells are formed. In certain embodiments, methods of treating or preventing vascular or diabetic diseases or conditions are contemplated. In certain embodiments, epigenetically reprogramming adult bone marrow-derived stem or progenitor cells including mesenchymal stem cells (MSCs) or endothelial progenitor cells (EPCs) for autologous treatments are contemplated.


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