The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2020
Filed:
Nov. 09, 2017
Applicant:
Wake Forest University Health Sciences, Winston-Salem, NC (US);
Inventor:
Khalil Bitar, Winston-Salem, NC (US);
Assignee:
Wake Forest University Health Sciences, Winston-Salem, NC (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61F 2/04 (2013.01); A61F 2/00 (2006.01); C12N 5/071 (2010.01); A61F 2/08 (2006.01); A61L 27/20 (2006.01); A61L 27/38 (2006.01); A61K 35/34 (2015.01);
U.S. Cl.
CPC ...
A61F 2/04 (2013.01); A61F 2/0004 (2013.01); A61F 2/08 (2013.01); A61K 35/34 (2013.01); A61L 27/20 (2013.01); A61L 27/383 (2013.01); A61L 27/3826 (2013.01); A61L 27/3834 (2013.01); A61L 27/3873 (2013.01); A61L 27/3886 (2013.01); C12N 5/0697 (2013.01); A61F 2002/045 (2013.01); A61L 2430/30 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2502/088 (2013.01); C12N 2502/1347 (2013.01);
Abstract
Methods are disclosed for forming tissue engineered, tubular bowel constructs from intestinal circular smooth muscle cells and enteric neural progenitor cells. The intestinal smooth muscle cells and neural progenitor cells can be seeded on a mold with a surface texture that induces longitudinal alignment of the intestinal smooth muscle cells and co-cultured until an innervated aligned smooth muscle sheet is obtained. The innervated smooth muscle sheet can then be wrapped around a tubular scaffold to form an intestinal tissue construct.