The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 03, 2020

Filed:

Jul. 11, 2018
Applicant:

Robert Bosch Gmbh, Stuttgart, DE;

Inventors:

Young Shik Shin, Mountain View, CA (US);

Nadezda Fomina, Redwood City, CA (US);

Christopher Johnson, Mountain View, CA (US);

Christoph Lang, Sunnyvale, CA (US);

Patrick Staley, Sunnyvale, CA (US);

Assignee:

Robert Bosch GmbH, Stuttgart, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 27/327 (2006.01); G01N 27/30 (2006.01); G01N 33/53 (2006.01); G01N 33/533 (2006.01); G01N 33/84 (2006.01); G01N 33/537 (2006.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
G01N 27/3275 (2013.01); G01N 27/302 (2013.01); G01N 33/533 (2013.01); G01N 33/5306 (2013.01); G01N 33/5375 (2013.01); G01N 33/5438 (2013.01); G01N 33/54386 (2013.01); G01N 33/84 (2013.01); G01N 27/3272 (2013.01); G01N 33/5304 (2013.01); G01N 33/54306 (2013.01);
Abstract

A method for detecting a presence and/or a concentration of a target substance in a reagent solution using enzyme-linked immunosorbent assay (ELISA) includes binding the target substance directly or indirectly to an electrode, and binding a detection agent directly or indirectly to the bound target substance. The method further includes modulating a pH of only a portion of the reagent solution in which the bound target substance and the bound detection agent are located using the electrode, the modulated pH of the portion of the reagent solution causing the bound detection agent to undergo a change, and detecting the change in the bound detection agent. The detected change corresponds to the presence of the target substance in the reagent solution and/or the concentration of the target substance in the reagent solution.


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