The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 03, 2020

Filed:

Oct. 30, 2017
Applicant:

University of Maryland, College Park, MD (US);

Inventors:

Jeffrey M Burke, Rockville, MD (US);

Ian M White, Rockville, MD (US);

Assignee:

University of Maryland, College Park, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01D 21/00 (2006.01); B01D 21/26 (2006.01); G01N 1/34 (2006.01); G01N 1/40 (2006.01); B60L 3/00 (2019.01); B01L 3/00 (2006.01); B01D 21/24 (2006.01);
U.S. Cl.
CPC ...
G01N 1/34 (2013.01); B01D 21/0087 (2013.01); B01D 21/2444 (2013.01); B01D 21/265 (2013.01); B01L 3/502753 (2013.01); B01L 3/502776 (2013.01); G01N 1/4077 (2013.01); B01L 2200/0636 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0816 (2013.01);
Abstract

A spiral inertial filtration device is capable of high-throughput (1 mL/min), high-purity particle separation while concentrating recovered target particles by more than an order of magnitude. Large fractions of sample fluid are removed from a microchannel without disruption of concentrated particle streams by taking advantage of particle focusing in inertial spiral microfluidics, which is achieved by balancing inertial lift forces and Dean drag forces. To enable the calculation of channel geometries in the device for specific concentration factors, an equivalent circuit model was developed and experimentally validated. Large particle concentration factors were achieved by maintaining either average fluid velocity or Dean number throughout the entire length of the channel during the incremental removal of sample fluid. Also provided is the ability to simultaneously separate more than one particle from the same sample.


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