The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2020
Filed:
Dec. 11, 2018
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Christian Mueller, Worcester, MA (US);
Florie Borel, Saint Martin, FR;
Assignee:
University of Massachusetts, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/00 (2006.01); A01K 67/027 (2006.01); C12N 15/85 (2006.01); C07K 14/81 (2006.01); C12N 15/09 (2006.01); C12N 15/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/8509 (2013.01); A01K 67/0276 (2013.01); C07K 14/8125 (2013.01); C12N 15/09 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0306 (2013.01); C12N 15/00 (2013.01); C12N 2015/8527 (2013.01);
Abstract
Transgenic non-human animals, e.g., rodents, e.g., mice comprising genomic mutations that inactive all of the serpin1A genes and thus lack any functional serpinA1 genes. As a result of the genomic mutations, the animals express no hepatic or circulatory AAT protein. Also provided herein are cells and tissues derived from the transgenic mice.