The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2020
Filed:
Oct. 22, 2019
Eureka Therapeutics, Inc., Emeryville, CA (US);
Hong Liu, El Sobrante, CA (US);
Pengbo Zhang, Fremont, CA (US);
Lucas Horan, Emeryville, CA (US);
Yiyang Xu, Pleasanton, CA (US);
Binnaz K. Staley, San Carlos, CA (US);
Lianxing Liu, San Francisco, CA (US);
Hongruo Yun, San Francisco, CA (US);
EUREKA THERAPEUTICS, INC., Emeryville, CA (US);
Abstract
The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.