The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 03, 2020

Filed:

Jun. 13, 2018
Applicant:

Sage Therapeutics, Inc., Cambridge, MA (US);

Inventors:

Gabriel Martinez Botella, Wayland, MA (US);

Boyd L. Harrison, Princeton Junction, NJ (US);

Albert Jean Robichaud, Cambridge, MA (US);

Francesco G. Salituro, Marlborough, MA (US);

Richard Thomas Beresis, Shanghai, CN;

Assignee:

Sage Therapeutics, Inc., Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07J 21/00 (2006.01); C07J 43/00 (2006.01); C07J 1/00 (2006.01); C07J 7/00 (2006.01); C07J 13/00 (2006.01); C07J 31/00 (2006.01); C07J 71/00 (2006.01);
U.S. Cl.
CPC ...
C07J 43/003 (2013.01); C07J 1/007 (2013.01); C07J 1/0059 (2013.01); C07J 1/0074 (2013.01); C07J 7/002 (2013.01); C07J 7/007 (2013.01); C07J 7/0085 (2013.01); C07J 13/007 (2013.01); C07J 21/00 (2013.01); C07J 31/006 (2013.01); C07J 71/001 (2013.01);
Abstract

Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, status epilepticus.


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