The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2020
Filed:
Nov. 08, 2017
Zhejiang University, Zhejiang, CN;
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, CN;
Tao Liu, Zhejiang, CN;
Jia Li, Shanghai, CN;
Yongzhou Hu, Zhejiang, CN;
Yubo Zhou, Shanghai, CN;
Xiaowu Dong, Zhejiang, CN;
Anhui Gao, Shanghai, CN;
Pinrao Song, Zhejiang, CN;
Peipei Wang, Shanghai, CN;
Lexian Tong, Zhejiang, CN;
Xiaobei Hu, Shanghai, CN;
Mingbo Su, Shanghai, CN;
ZHEJIANG UNIVERSITY, Zhejiang, CN;
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai, CN;
Abstract
A 2-substituted aromatic ring-pyrimidine derivative as shown in a general formula I, and an optical isomer or a pharmaceutically acceptable salt or a solvate thereof are provided. The present invention designs and synthesizes a series of novel small molecular Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained through structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess strong anti-cancer effect, Chk1 kinase inhibitory activity and are promising Chk1 inhibitors. The compounds can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal.