The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 03, 2020

Filed:

Aug. 22, 2017
Applicant:

North Carolina State University, Raleigh, NC (US);

Inventors:

Joshua G. Pierce, Raleigh, NC (US);

Grant A. Edwards, Raleigh, NC (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 263/40 (2006.01); A01N 43/76 (2006.01); A61L 31/08 (2006.01); A61L 31/16 (2006.01); A61P 31/04 (2006.01); A61L 29/16 (2006.01); A61L 27/54 (2006.01);
U.S. Cl.
CPC ...
C07D 263/40 (2013.01); A01N 43/76 (2013.01); A61L 27/54 (2013.01); A61L 29/16 (2013.01); A61L 31/08 (2013.01); A61L 31/16 (2013.01); A61P 31/04 (2018.01); A61L 2300/204 (2013.01); A61L 2300/404 (2013.01);
Abstract

Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biofilms. The compounds can also exhibit activity against Gram negative biofilms. In some cases, the compounds can exhibit both biofilm modulation properties and antimicrobial activity. Compositions comprising these compounds, as well as methods of using thereof, are also described. For example, the compounds described herein can be used in human and animal health (e.g., for the treatment of infection), agriculture, marine coatings, and other coating applications related to prevention of biofilm (e.g., dental, medical, etc.).


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