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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10821193 B1

PDFFull Text
Date of Patent:
Nov. 03, 2020

Filed:

Sep. 16, 2015

Adeno-associated viral vectors for treating myocilin (myoc) glaucoma

Applicant:

Genzyme Corporation, Cambridge, MA (US);

Inventors:

Peter Pechan, Newton, MA (US);

Abraham Scaria, Framingham, MA (US);

Jeffery Ardinger, Bridgewater, NJ (US);

Assignee:

GENZYME CORPORATION, Cambridge, MA (US);

Attorney:

Morrison & Foerster LLP

Primary Examiner:

Maria Marvich

Int. Cl.
CPC ...
C12N 15/864 (2006.01); A61K 48/00 (2006.01); C07K 14/47 (2006.01); C12N 15/113 (2010.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); C12N 15/11 (2006.01); A61K 9/00 (2006.01); A61K 38/17 (2006.01); C12N 15/12 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0058 (2013.01); A61K 9/0048 (2013.01); A61K 38/1709 (2013.01); C07K 14/47 (2013.01); C12N 7/00 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/86 (2013.01); A61K 48/0075 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2320/31 (2013.01); C12N 2330/51 (2013.01); C12N 2750/14132 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14171 (2013.01);
Abstract

Provided herein are methods for treating myocilin (MYOC) glaucoma using adeno-associated viral (AAV) vectors. In some aspects, the AAV vectors encode R-spondin 1 (RSPO1), R-spondin 2 (RSPO2), R-spondin 3 (RSPO3) or R-spondin 4 (RSPO4) and/or RNAi that targets myocilin (MYOC). In one aspect, viral particles are administered to the eye of a human subject. Viral particles encoding RSPO1, RSPO2, RSPO3 and/or RSPO4 and/or MYOC RNAi are contemplated. In some aspects, variant AAV2 particles that transduce the trabecular meshwork are provided.

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Pechan, Peter. (2020). Adeno-associated viral vectors for treating myocilin (myoc) glaucoma (U.S. Patent No. 10821193). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10821193

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