The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2020
Filed:
Mar. 01, 2017
Applicant:
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Inventors:
Arnon Lavie, Chicago, IL (US);
Hien-Anh Nguyen, Chicago, IL (US);
Assignee:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, Urbana, IL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/82 (2006.01); C12N 15/00 (2006.01); A61K 38/50 (2006.01); C07K 14/52 (2006.01); A61K 47/66 (2017.01); A61K 47/68 (2017.01); A61K 47/65 (2017.01); A61P 35/00 (2006.01); C12N 15/52 (2006.01); C12R 1/18 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/50 (2013.01); A61K 47/65 (2017.08); A61K 47/67 (2017.08); A61K 47/6815 (2017.08); A61P 35/00 (2018.01); C07K 14/52 (2013.01); C12N 9/82 (2013.01); C12N 15/52 (2013.01); C12R 1/18 (2013.01); C12Y 305/01001 (2013.01); A61K 38/00 (2013.01); C07K 2319/35 (2013.01); C07K 2319/74 (2013.01); Y02A 50/473 (2018.01);
Abstract
VariantL-asparaginases with reduced L-glutaminase activity and enhanced in vivo circulation are described as are fusion proteins containing an L-asparaginase and three tandem soluble domains of TRAIL for use in the treatment of cancers such as acute lymphoblastic leukemia and acute myeloid leukemia.