The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2020
Filed:
Apr. 07, 2016
Applicant:
Genzyme Corporation, Cambridge, MA (US);
Inventors:
Sirkka Kyostio-Moore, Ashland, MA (US);
David Souza, Waltham, MA (US);
Karen Vincent, Carlisle, MA (US);
Assignee:
Genzyme Corporation, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 38/17 (2006.01); A61P 11/00 (2006.01); A61P 21/00 (2006.01); C12N 7/00 (2006.01); C07K 14/755 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 38/1709 (2013.01); A61P 11/00 (2018.01); A61P 21/00 (2018.01); C07K 14/755 (2013.01); C12N 7/00 (2013.01); C12N 2710/10041 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14152 (2013.01);
Abstract
Provided herein are methods for producing an adeno-associated virus (AAV) particle containing an oversized recombinant AAV genome (e.g., greater than 4.7 kb). In some aspects, the invention provides AAV particles and AAV vectors comprising oversized rAAV genomes. Producer cell lines to produce AAV particles comprising oversized genomes are also provided.