The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2020
Filed:
Jul. 05, 2018
Applicant:
The Research Foundation for the State University of New York, Albany, NY (US);
Inventors:
Li Niu, Loudonville, NY (US);
Zhen Huang, Great Falls, VA (US);
Assignee:
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, Albany, NY (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/115 (2010.01); A61P 25/28 (2006.01); A61P 29/02 (2006.01);
U.S. Cl.
CPC ...
C12N 15/115 (2013.01); A61P 25/28 (2018.01); A61P 29/02 (2018.01); C12N 2310/16 (2013.01); C12N 2310/322 (2013.01);
Abstract
Disclosed is an RNA aptamer, a synthetic oligonucleotide of 2'-fluoro-modified A, U, and C nucleotides, with improved stability compared to its unmodified counterpart. Like the unmodified aptamer, however, the modified version is a potent glutamate receptor antagonist. Additionally, the RNA aptamers described herein are water soluble by nature, and generally exhibit nano- to micromolar potency making them potential therapeutic agents for the treatment of neurological disorders involving glutamate receptor activity.