The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2020
Filed:
Dec. 16, 2015
Applicant:
Roche Innovation Center Copenhagen A/s, Horsholm, DK;
Inventors:
Henrik Frydenlund Hansen, Horsholm, DK;
Troels Koch, Horsholm, DK;
Sabine Sewing, Basel, CH;
Nanna Albaek, Horsholm, DK;
Peter Hagedorn, Horsholm, DK;
Jacob Ravn, Horsholm, DK;
Christoph Rosenbohm, Hørsholm, DK;
Annie Moisan, Basel, CH;
Marcel Gubler, Basel, CH;
Assignee:
Roche Innovation Center Copenhagen A/S, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 15/11 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 15/111 (2013.01); G01N 33/5014 (2013.01); G01N 33/5088 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/341 (2013.01); C12N 2310/345 (2013.01); C12N 2310/346 (2013.01); C12N 2320/53 (2013.01); C12N 2330/31 (2013.01);
Abstract
The invention relates to a method of identifying stereodefined phosphorothioate oligonucleotide variants with reduced toxicity by creating and screening libraries of stereodefined chiral phosphorothioate variants for compounds with reduced toxicity, either in vitro or in vivo.